Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production
| Autor: | Dongho Lee, Haeun Kwon, Thi Phuong Linh Le, Jin Tae Hong, Jun Gu Kim, Jin Woo Lee, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong Lee, Jae Sang Han |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Circular dichroism biology Diacetylene 010405 organic chemistry Stereochemistry Organic Chemistry Pharmaceutical Science biology.organism_classification Inhibitory postsynaptic potential 01 natural sciences 0104 chemical sciences Analytical Chemistry Nitric oxide 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery Ic50 values Molecular Medicine Aralia cordata |
| Zdroj: | Journal of Natural Products. 84:230-238 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c00842 |
| Popis: | Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane diterpenoids (1-4) and a diacetylene (5) together with 21 known compounds (6-26). Their structures were established based on the interpretation of one- and two-dimensional NMR and HRESIMS data. The absolute configurations of the new isolates were determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, and Mosher's esterification method. All compounds exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values ranging from 1.1 to 69.4 μM. |
| Databáze: | OpenAIRE |
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