Apple cider vinegar attenuates lipopolysaccharide-induced neurobehavioral deficits in mice
| Autor: | Osasenaga Macdonald Ighodaro, Michael A. Abiola, A.M. Adeosun, Benneth Ben-Azu, Folake O. Asejeje, Abayomi M. Ajayi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Elevated plus maze Physiology Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Pharmacology medicine.disease_cause Biochemistry Open field Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine 030109 nutrition & dietetics Nutrition and Dietetics business.industry Public Health Environmental and Occupational Health Glutathione Malondialdehyde Apple cider vinegar chemistry business Oxidative stress Food Science Behavioural despair test |
| Zdroj: | Nutrire. 45 |
| ISSN: | 2316-7874 |
| DOI: | 10.1186/s41110-020-00125-1 |
| Popis: | Apple cider vinegar (ACV), an acidic solution usually obtained from apple’s fermentation, is rich in polyphenols, compounds whose protective effects against neurodegenerative diseases is well documented. In view of this, the present study sought to evaluate the potential of ACV to attenuate lipopolysaccharide (LPS)-induced neurobehavioral deficits. Twenty-four Swiss mice randomly grouped into four (n = 6) were used for the study. Group 1 received normal saline, group 2 (LPS control) also received normal saline, while groups 3 and 4 respectively received ACV (10 mL/kg) for 7 days. LPS (0.5 mg/kg) was injected into animals in groups 2 and 4. Twenty-four hours (24 h) later, neurobehavioral deficits were evaluated in the animals using open field test (OFT), walk beam test (WBT), elevated plus maze (EPM), and forced swimming test (FST). Proinflammatory cytokines (TNF-α and IL-6) and nitrite, as well as malondialdehyde, reduced glutathione, and catalase activity, were assayed as biomarkers of brain inflammation and oxidative stress, respectively. The WBT, EPM, and FST analyses showed that pretreatment with ACV significantly (P |
| Databáze: | OpenAIRE |
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