(4+1)-Cycloadditions Exploiting the Biphilicity of Oxyphosphonium Enolates and RhII/PdII-Stabilized Metallocarbenes for the Construction of Five-Membered Frameworks

Autor:	Brandon L. Ashfeld, Zachary D. Tucker
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Cyclopropanation Chemistry Stereochemistry Organocatalysis Organic Chemistry Synthon Migratory insertion chemistry.chemical_element Reactivity (chemistry) Carbene Reductive elimination Rhodium
Zdroj:	Synlett. 32:1157-1168
ISSN:	1437-2096 0936-5214
Popis:	(4+1)-Cyclizations are an underutilized disconnect for the formation of five-membered heterocyclic and carbocyclic frameworks. Herein we analyze methods employing oxyphosphonium enolates and RhII/PdII-metallocarbenes as C1 synthons in the presence of several four-atom components for the synthesis of 2,3-dihydrobenzofurans, 2,3-dihydroindoles, oxazolones, cyclopentenones, and pyrrolones.1 Introduction2 (4+1)-Cyclizations Employing Kukhtin–Ramirez-Like Reactivity3 (4+1)-Cyclizations Employing a Cyclopropanation/Ring-Expansion Sequence4 Pd-Catalyzed (4+1)-Cyclizations through Carbene Migratory Insertion/Reductive Elimination Processes5 Summary
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::45bc9b307d534b6200c44feecc771caf https://doi.org/10.1055/s-0040-1706009 Zobrazit plný text záznamu