Assessment of cardiotoxic potential of methanol extract of red cultivar Allium cepa
| Autor: | O. O. Oni, Olayinka A. Oridupa, J. A. Oyewusi, MF Mshelbwala, Adebowale Bernard Saba, I. K. Oyewusi |
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| Rok vydání: | 2017 |
| Předmět: |
Cardiotoxicity
biology medicine.diagnostic_test business.industry Cardiac muscle food and beverages biology.organism_classification Toxicology 03 medical and health sciences Red blood cell 0302 clinical medicine Animal science medicine.anatomical_structure Oral administration Troponin I Medicine Allium Cultivar 030223 otorhinolaryngology business Mean corpuscular volume 030217 neurology & neurosurgery |
| Zdroj: | Sokoto Journal of Veterinary Sciences. 15:69 |
| ISSN: | 1595-093X |
| Popis: | The effects of oral administration of crude methanol extract of red cultivar Allium cepa (Onion) on serum cardiac troponin (cTnI) in cardiac muscle and some haematological parameters were investigated in this study. Fifty five (55) male albino rats were housed and fed with standard growers ration and water ad libitum . There were three major groups; A, B and C containing twenty five (25), twenty five (25) and five (5) rats respectively. Group C was the control group while groups A and B were sub-divided into 5 groups of 5 rats each. Group A was administered with red cultivar A. cepa extract at doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg and 1200 mg/kg for 14 days while group B rats were administered with the doses of red cultivar A. cepa for 28 days. Blood samples were collected from the retro-orbital sinus for haematology and cardiac troponin-I assay, histopathological examination of the heart was also done. Haematology showed significant (p |
| Databáze: | OpenAIRE |
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