Diffusion lung capacity for carbon monoxide (DLCO) is an independent prognostic factor for long-term survival after curative lung resection for cancer
| Autor: | Sanjib Basu, Michael C. Hoaglin, Michael J. Liptay, Zane Hammoud, William H. Warren, L. Penfield Faber, Anthony W. Kim, Neil Freedman |
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| Rok vydání: | 2009 |
| Předmět: |
Lung cancer surgery
medicine.medical_specialty Lung business.industry Cancer General Medicine respiratory system medicine.disease Gastroenterology Pulmonary function testing Surgery medicine.anatomical_structure Oncology DLCO Internal medicine medicine Lung volumes Stage (cooking) Lung cancer business |
| Zdroj: | Journal of Surgical Oncology. 100:703-707 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.21407 |
| Popis: | Introduction We examined the early and late prognostic significance of DLCO and forced expiratory volume in 1 sec (FEV1) in patients who underwent surgical resection of lung cancer. Methods From 1997 to 2004, 462 patients underwent successful complete resection of their lung cancer and had full pulmonary function testing including DLCO performed. Mean follow-up was over 5 years (64.8 months—range: 0–158 months). Results Postoperative 90-day mortality was 2.6% (12/462). At last follow-up, of the remaining 450 patients, 182 patients were alive, 130 had died of cancer, and 138 have died of other causes and did not have recurrent cancer. Mean DLCO values were 69.4%, 66.8%, and 53.9%, respectively. Mean FEV1 values were 81.3%, 78.1%, and 71.5%, respectively. Mean DLCOs and FEV1s between patients who died of cancer versus other causes were significantly different (P |
| Databáze: | OpenAIRE |
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