The protective effects of Ginkgo biloba extract (EGb-761) on radiation-induced dermatitis: an experimental study
| Autor: | E. Karahacioglu, S. Omeroglu, D. Kilic, E. Yirmibesoglu, G. Akbulut, N. Lortlar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant biology business.industry Ginkgo biloba medicine.medical_treatment Radiation-Induced Dermatitis Dermatology Glutathione biology.organism_classification medicine.disease_cause Malondialdehyde Nitric oxide Proliferating cell nuclear antigen chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein business Oxidative stress |
| Zdroj: | Clinical and Experimental Dermatology. 37:387-394 |
| ISSN: | 0307-6938 |
| Popis: | Summary Background. Irradiation of the skin induces production of free radicals, resulting in oxidative stress. EGb-761, an extract from the leaves of the Ginkgo biloba tree, has been reported to be an effective exogenous antioxidant based on its free-radical scavenger properties. Aim. To investigate the protective effect of G. biloba extract (EGb-761) on radiation-induced dermatitis in rats. Methods. Forty male Wistar rats were divided equally into four groups: group 1 received sham radiotherapy (RT) without EGb-761, group 2 received sham RT with EGb-761, group 3 received RT without EGb-761, and group 4 received RT with EGb-761. Levels of malondialdehyde (MDA), nitric oxide (NOx) and glutathione (GSH) were measured. Dermatitis was assessed with a semiquantitative dermatitis item score. The intensity of staining and diffusion of expression for proliferating cellular nuclear antigen (PCNA) and transforming growth factor (TGF)-β3 were also evaluated. Results. The enhanced oxidative stress seen after RT was markedly diminished when EGb-761 was administered with RT; significantly lower mean MDA (P |
| Databáze: | OpenAIRE |
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