| Autor: |
Frederick Naftolin, Dennis A. Robbins, Michael L. Millenson, Frederick A. Curro, Chester H. Fox |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
The Journal of Clinical Pharmacology. 53:1091-1094 |
| ISSN: |
0091-2700 |
| DOI: |
10.1002/jcph.138 |
| Popis: |
Practice‐based research networks (PBRNs) can function as a platform for delivery of patient‐centered care consistent with the Patient Protection and Affordable Care Act. Patient‐centered (centric) clinical studies encourage the patient to be an integral part of study design and outcome. The patient’s electronic health record contributes to the shared national health care data set. PBRNs integrate health care data in real time at the point of care and reflectthefullcontextoftheperson’shealth.PBRNsdesignedundertheprinciplesofgoodclinicalpractice(GCP)validatestudiesrelatedtocomparative effectiveness research and drug development. PBRNs can generate large amounts of data from known patient histories so that side effects can be assessed in their totality. The larger and more diverse number of patients recruited suggests that point‐of‐care‐data, where both provider and patient participate in the treatment, may be more robust in that side effects, drug–drug interactions and number of concomitant medications used may be identified earlier in the development process. The GCP PBRN concept affords continuous patient information for both care and research purposes. Theseallcontributetoanethicalapproachforthepharmaceuticalindustrytogenerateclinicalresearchdataforregulatorysubmissionandtocontribute to a HIPAA‐compliant national database that could contribute to improved health care delivery and pharmacovigilance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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