Comparative study of dual energy X-ray absorptiometry and quantitative ultrasonography with the use of biochemical markers of bone turnover in boys with haemophilia
| Autor: | Eirini Kazantzidou, V Tzimouli, Nikolaos Gompakis, Athanasios Christoforidis, Miranda Athanassiou-Metaxa, Ioanna Tsatra, Evangelia Farmaki, Eleni Papadopoulou, Marina Economou |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
musculoskeletal diseases
Bone mineral medicine.medical_specialty biology medicine.diagnostic_test business.industry Osteoporosis Hematology General Medicine medicine.disease Haemophilia Bone remodeling Endocrinology Osteoprotegerin Internal medicine medicine Osteocalcin biology.protein Tibia business Nuclear medicine Genetics (clinical) Dual-energy X-ray absorptiometry |
| Zdroj: | Haemophilia. 17:e217-e222 |
| ISSN: | 1351-8216 |
| DOI: | 10.1111/j.1365-2516.2010.02385.x |
| Popis: | Our aim was to evaluate bone status in boys with haemophilia using dual energy X-ray absorptiometry (DXA) and quantitative ultraSonography (QUS), and in addition, to compare these two methods with the use of biochemical markers of bone turnover. Twenty-six boys with a mean decimal age of 12.08 ± 4.44 years were included in the study which included a DXA scan at lumbar spine and radial, as well as tibial QUS. Serum levels of soluble receptor activator of nuclear factor κB ligand (sRANK-L), osteoprotegerin (OPG) and osteocalcin (OC) were measured and joint evaluation was performed using the Hemophilia Joint Health Score (HJHS). With regard to the study results, only 2 of 26 patients (7.7%) had bone mineral density (BMD) Z-scores < -2, and 4 patients (15.4%) had BMD Z-scores between -1 and -2. Only one patient had radial and other two had tibial QUS Z-scores < -2. No agreement was recorded between QUS and DXA in identifying patients at risk for osteoporosis (k = 0.275, P = 0.063). Haemophiliacs had significantly higher serum levels of sRANK-L (21.04 ± 4.78 vs. 18.58 ± 2.28 ng mL(-1), P = 0.038) and of OC (5.35 ± 2.29 vs. 3.09 ± 0.61 ng mL(-1), P = 0.002) and significantly decreased levels of OPG (15.78 ± 2.53 vs. 23.79 ± 4.39 pg mL(-1), P < 0.001) compared with controls. QUS Z-scores at tibia significantly correlated with HJH Scores (r = -0.450, P = 0.040), whereas lumbar BMD Z-scores significantly correlated with body mass index Z-scores (r = 0.500, P = 0.009). More studies are warranted to identify the most accurate densitometric method for assessing bone status in haemophiliacs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text