An Optimized Radiomics Model Based on Automated Breast Volume Scan Images to Identify Breast Lesions

Autor: Shunlin Guo, Kongqiang Zhu, Sumei Ma, Hui Wang, Xinwu Yang
Rok vydání: 2021
Předmět:
Zdroj: Journal of Ultrasound in Medicine. 41:1643-1655
ISSN: 1550-9613
0278-4297
DOI: 10.1002/jum.15845
Popis: OBJECTIVES To develop and test an optimized radiomics model based on multi-planar automated breast volume scan (ABVS) images to identify malignant and benign breast lesions. METHODS Patients (n = 200) with breast lesions who underwent ABVS examinations were included. For each patient, 208 radiomics features were extracted from the ABVS images, including axial plane and coronal plane. Recursive feature elimination, random forest, and chi-square test were used to select features. A support vector machine, logistic regression, and extreme gradient boosting were utilized as classifiers to differentiate malignant and benign breast lesions. The area under the curve, sensitivity, specificity, accuracy, and precision was used to evaluate the performance of the radiomics models. Generalization of the radiomics models was verified through 5-fold cross-validation. RESULTS For a single plane or a combination of planes, a combination of recursive feature elimination, and support vector machine yielded the best performance when identifying breast lesions. The machine learning models based on a combination of planes performed better than those based on a single plane. Regarding the axial plane and coronal plane, the machine learning model using a combination of recursive feature elimination and support vector machine yielded the optimal identification performance: average area under the curve (0.857 ± 0.058, 95% confidence interval, 0.763-0.957); the average values of sensitivity, specificity, accuracy, and precision were 87.9, 68.2, 80.7, and 82.9%, respectively. CONCLUSIONS The optimized radiomics model based on ABVS images can provide valuable information for identifying benign and malignant breast lesions preoperatively and guide the accurate clinical treatment. Further external validation is required.
Databáze: OpenAIRE
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