Growth Hormone-Binding Protein in Normal and Pathologic Gestation: Correlations with Maternal Diabetes and Fetal Growth1
| Autor: | H. D. McIntyre, Ross Barnard, F. Y. Chan |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Fetus
medicine.medical_specialty Pregnancy Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Biology medicine.disease Biochemistry Pathophysiology Endocrinology Growth hormone-binding protein Internal medicine Diabetes mellitus Blood plasma medicine Gestation Mass index |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 82:1879-1884 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | To date, measurements of GH-binding protein (GHBP) during human pregnancy have been carried out using assays susceptible to interference by the elevated levels of human placental GH typical of late gestation. We recruited a large cohort of pregnant women (n = 140) for serial measurements of GHBP and used the ligand immunofunctional assay for GHBP. For normal gravidas, GHBP levels fell throughout gestation. Mean levels were 1.07 nmol/L (se = 0.18) in the first trimester, 0.90 nmol/L (se = 0.08) at 18–20 weeks, 0.73 nmol/L (se = 0.05) at 28–30 weeks, and 0.62 nmol/L (se = 0.06) at 36–38 weeks. GHBP levels in the first trimester correlated significantly with maternal body mass index (r = 0.58; P < 0.01). GHBP levels in pregnancies complicated by noninsulin-dependent diabetes mellitus (NIDDM) were substantially elevated at all gestational ages. The mean value in the first quarter (2.29 nmol/L) was more than double the normal mean (P < 0.01). In contrast, patients with insulin-dependent diabetes mellitus (IDDM... |
| Databáze: | OpenAIRE |
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