ChemInform Abstract: Novel Approach for the Conversion of Natural Δ3Cephalosporin Derivatives into Corresponding Δ2Cephalosporin Derivatives

Autor:	Andra Naidu, Korrapati V. V. Prasada Rao, Ramesh Dandala, Ananta Rani, Inti V. Subramanyeswara Rao, Anand Gopalkrishna Kamat, Vija Y. K. Handa
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Cephem Trimethylsilyl Double bond Silylation medicine.drug_class Cephalosporin General Medicine Combinatorial chemistry chemistry.chemical_compound chemistry mental disorders polycyclic compounds medicine Triethylamine Isomerization Acetamide
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200812227
Popis:	A simple one pot synthetic method for the isomerization of cephem double bond from the natural 3-position to 2-cephem positions is affected by silylation. Thus cephalosporin acids are treated with Ntrimethylsilylacetamide (MSA) or N,O-bis(trimethylsilyl)acetamide (BSA) and the resulting silyl esters are treated with triethylamine at ambient temperature in the same pot to afford Δ2-cephalosporins, which are potentially related compounds in cephalosporin antibacterial compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::459f2295ad5cd1904d259b6d18bb78e4 https://doi.org/10.1002/chin.200812227 Zobrazit plný text záznamu Plný text