Excess serum osmolality gap after ingestion of methanol: a methodology-associated phenomenon?

Autor:	Ronny Daelemans, P. Demedts, Hugo Neels, F. Franck, A Wauters, L Theunis
Rok vydání:	1994
Předmět:	Ethanol Chromatography Biochemistry (medical) Clinical Biochemistry Metabolic acidosis Alcohol medicine.disease Osmolar Concentration chemistry.chemical_compound chemistry Methanol poisoning medicine Ingestion Methanol Quantitative analysis (chemistry)
Zdroj:	Clinical Chemistry. 40:1587-1590
ISSN:	1530-8561 0009-9147
Popis:	A patient intentionally ingested an unknown amount of methanol and was admitted to the hospital 6 h later. On admission, the methanol concentration in blood was estimated as approximately of 134 mmol/L, based on the calculation of the osmolal gap. Intravenous ethanol administration and hemodialysis were promptly started. During hemodialysis, several blood samples were collected for determination of methanol and ethanol concentrations. Initially, we used gas chromatography with split-mode injection of pretreated serum samples; however, methanol concentrations turned out to be significantly lower than expected, based on calculated osmolal gap values. Because no explanation for the excess serum osmolal gap was apparent, we reanalyzed samples, using head-space gas chromatography. The methanol concentrations measured were significantly higher and osmolal gap values were no longer excessive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::459af37b6a74e2890aff503b483b433b https://doi.org/10.1093/clinchem/40.8.1587 Zobrazit plný text záznamu