A New Flavone and Cytotoxic Constituents of Nicotiana tabacum

Autor:	Li Chai Chen, Jen Wen Hsiao, Jih Jung Chen, Hui Chu Huang, Lih Chi Chen, Ming Jen Cheng, Sheng Kan Chien
Rok vydání:	2018
Předmět:	biology 010405 organic chemistry Stereochemistry Nicotiana tabacum Plant Science General Chemistry biology.organism_classification 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Rutin chemistry Cell culture Ic50 values Cytotoxic T cell Kaempferol Quercetin Solanaceae
Zdroj:	Chemistry of Natural Compounds. 54:1044-1047
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-018-2551-4
Popis:	A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2), quercetin (3), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (4), kaempferol (5), and rutin (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1) and 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2) exhibited cytotoxicities, with IC50 values of 2.24 ± 0.32 and 3.40 ± 0.21 μg/mL, respectively, against CCRF-CEM and P388D1 cell lines.
Databáze:	OpenAIRE
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