Quantitation of Regional Ventilation During the Washout Phase of Lung Scintigraphy
| Autor: | N. David Charkes, John M. Travaline, Alan H. Maurer, Gerard J. Criner, Satoshi Furukawa, Jean-Luc Urbain |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Lung business.industry Respiratory disease Environmental air flow Washout respiratory system Lung volume reduction surgery Critical Care and Intensive Care Medicine medicine.disease Ventilation/perfusion ratio respiratory tract diseases Surgery medicine.anatomical_structure Internal medicine medicine Cardiology Breathing Lung volumes Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 118:721-727 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.118.3.721 |
| Popis: | Study objectives We sought to investigate the effectof lung volume reduction surgery (LVRS) on regional lungventilation. Design Retrospective analysis ofroutinely acquired data before and after LVRS. Setting Large, urban, university medical center. Patients Twenty-nine patients with severe emphysema. Intervention Bilateral LVRS. Measurements and results 133 Xe washout curves during lungscintigraphy exhibit a biphasic pattern (the first component of thewashout curve [m r ] corresponds to an initial rapidphase in washout that reflects larger airways emptying, and the secondcomponent [m s ] reflects a slower phase of washout that isattributed to gas elimination via smaller airways). We analyzed sixstandardized regions of the lung (upper, mid, and lower zones of theright and left lung), and calculated m r and m s for each lung region. The mean (± SE) baseline FEV 1 was0.69 ± 0.04 L, total lung capacity (TLC) was 139 ± 4% predicted, and the residual volume (RV)/TLC ratio was 65 ± 2%. The meanimprovement in FEV 1 3 months post-LVRS was 38%. Post-LVRS,m r and m s increased in 79 and 74 lung regions, respectively, and there was no relationship with respect to lungregions that had or had not been operated on. The increase inm s , however, significantly correlated with the increase in, FEV 1 ( r = 0.66; p r = −0.67; p s also correlated with a decrease in, Pa co 2 ( r = −0.39;p = 0.03), but m r showed no relationship with anyparameter. Conclusions Small airways ventilation inlung regions that had and had not been operated on is associated with agreater improvement in lung mechanics following, LVRS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|