Familial thrombophilia and idiopathic intracranial hypertension
| Autor: | O.C. Backhouse, M.J. Menage, B.A. McVerry, N. Cawthray, D.R. Jamieson, P.J. Goulding, M. Johnson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Pediatrics biology business.industry Factor V Thrombophilia medicine.disease Thrombosis Surgery Intracranial venous sinus Raised intracranial pressure Cerebral Sinus Ophthalmology medicine biology.protein Prothrombin G20210A Neurology (clinical) business Familial thrombophilia |
| Zdroj: | Neuro-Ophthalmology. 25:135-141 |
| ISSN: | 1744-506X 0165-8107 |
| DOI: | 10.1076/noph.25.3.135.7127 |
| Popis: | Some cases of raised intracranial pressure, previously diagnosed as idiopathic intracranial hypertension (IIH), are now found to have intracranial venous sinus thrombosis which is linked to a prothrombotic state. This study looked at the prevalence of familial thrombophilia in cases of IIH with normal cerebral sinus imaging. Thirty patients with IIH, fulfilling the modified Dandy criteria, were prospectively enrolled to form the study group. All but two patients were female. All had a full risk-factor history taken and underwent investigation of rheological factors and thrombophilia, including tests for the factor V Leiden mutation, prothrombin G20210A allele, and hyperhomocysteinaemia. Ninety people made up the control group. Twenty-five patients had a normal thrombophilia screen. Two patients were heterozygous for the factor V mutation, two had mild raised levels of antiphospholipid antibodies, one of whom was transient, and one had reduced levels of free protein S. Both males and 28 females (90%) were ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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