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One of the main mechanisms in the pathogenesis of toxic liver damage is destabilization of the membranes of hepatocytes as a result of lipid peroxidation (LPO). In the case of such liver disorders, a pronounced protective action is offered by phenolic antioxidants such as -tocopherol [1], potassium phenosane, synthetic derivatives of hydroxycynnamic acids, ionol, ubiquinone, and some other natural compounds [2]. According to [3], some derivatives of hydroxycynnamic acids are superior to -tocopherol with respect to hepatoprotector action. The high hepatoprotector activity of hydroxycynnamic acid derivatives can be due to their hydrophilicity, which accounts for the high rate of transport and biological accessibility of these molecules. Below we report on a comparative study of the antioxidant activity and hepatoprotector properties of a series of water-soluble 2,6-di-tert-butyl-4-propylphenol derivatives (I – IV) and some analogous compounds (V – VIII) not containing tert-butyl groups. |
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