Synthesis of a heptapeptide forming a modified ACTH 4–10 fragment

Autor:	E. P. Krysin, S. Yu. Borovkova, V. N. Karel'skii, A. K. Rabinovich
Rok vydání:	1986
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Peptide Plant Science General Chemistry Optical rotation General Biochemistry Genetics and Molecular Biology Palladium black
Zdroj:	Chemistry of Natural Compounds. 22:706-709
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf00598358
Popis:	A scheme is given for the synthesis of a heptapeptide representing a modified ACTH 4–10 fragment on the basis of which it is possible to create a preparation that is an effective adaptogen of peptide nature. A proposed variant of the synthesis permits a peptide with an adequate degree of purity to be obtained comparatively simply on a larger scale. The intermediate compounds and the final products were obtained with good yields and were distinguished by chromatographic homogeneity. The heptapeptide synthesized did not differ with respect to its physicochemical characteristics and biological action from the analogous compound obtained previously. Some physicochemical characteristics of the compound obtained (angles of optical rotation, chromatographic mobilities) are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::458b5cc68e1543e62decdc64c1c04046 https://doi.org/10.1007/bf00598358 Zobrazit plný text záznamu Full text from SpringerLink