Diagnostic Value of Interferon-γ in Tuberculous Pleurisy
| Autor: | Qiu-Li Liang, Xue-Jun Qin, Huan-Zhong Shi, Jing Jiang, Shou-Ming Qin |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Receiver operating characteristic business.industry Pleural effusion Critical Care and Intensive Care Medicine medicine.disease Gastroenterology Likelihood ratios in diagnostic testing Confidence interval Surgery Pleural disease Pleurisy Internal medicine medicine Diagnostic odds ratio Differential diagnosis Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 131:1133-1141 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.06-2273 |
| Popis: | Background Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of interferon (IFN)-γ measurements in pleural fluid for the early diagnosis of tuberculous pleurisy. We conducted a metaanalysis to determine the accuracy of IFN-γ measurements in the diagnosis of tuberculous pleurisy. Methods After a systematic review of English-language studies, sensitivity, specificity, and other measures of accuracy of IFN-γ concentrations in the diagnosis of pleural effusion were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. Results Twenty-two studies met our inclusion criteria. The summary estimates for IFN-γ in the diagnosis of tuberculous pleurisy in the studies included were as follows: sensitivity, 0.89 (95% confidence interval [CI], 0.87 to 0.91); specificity, 0.97 (95% CI, 0.96 to 0.98); positive likelihood ratio, 23.45 (95% CI, 17.31 to 31.78); negative likelihood ratio, 0.11 (95% CI, 0.07 to 0.16); and diagnostic odds ratio, 272.7 (95% CI, 147.5 to 504.2). Conclusions IFN-γ determination is a sensitive and specific test for the diagnosis of tuberculous pleurisy. The measurement of IFN-γ levels in pleural effusions is thus likely to be a useful tool for diagnosing tuberculous pleurisy. The results of IFN-γ assays should be interpreted in parallel with clinical findings and the results of conventional tests. |
| Databáze: | OpenAIRE |
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