Emergence and spread of the potential variant of interest (VOI) B.1.1.519 predominantly present in Mexico

Autor: Juan Pablo Reyes-Grajeda, Fernando Penaloza-Figueroa, Luis Alonso Herrera-Montalvo, Dulibeth Gonzalez-Barrera, Tatiana Ernestina Nuñez-García, Alfredo Mendoza-Vargas, Alberto Cedro-Tanda, Alejandro Sanchez-Flores, José Esteban Muñoz-Medina, Jorge Salas-Hernández, Natividad Cruz-Ortiz, Gisela Barrera-Badillo, Blanca Taboada, Alfredo Hidalgo-Miranda, Abril Paulina Rodríguez-Maldonado, Lucía Hernández-Rivas, Santiago Ávila-Ríos, Concepción Grajales-Muñiz, Nicolas Alcaraz, Irma López-Martínez, Margarita Matías-Florentino, Joel A. Vazquez-Perez, Fidencio Mejía-Nepomuceno, José Ernesto Ramírez-González, Mario Mujica-Sanchez, Celia Boukadida, Alejandra Hernández-Terán, Carlos F. Arias, Rogelio Pérez-Padilla, Pavel Isa, Daniel Rangel-DeLeon, Eduardo Becerril-Vargas, Angel Gustavo Salas-Lais, Andrea Santos Coy-Arechavaleta, Claudia Wong-Arámbula, José Arturo Martínez-Orozco
Rok vydání: 2021
Předmět:
Popis: SARS-CoV-2 variants have emerged in late 2020 and there are at least three variants of concern (B.1.1.7, B.1.351, P1) reported by WHO. These variants have several substitutions in the Spike protein that affect receptor binding; they present increased transmissibility and may be associated with reduced vaccine effectiveness. In the present work, we are reporting the identification of a potential variant of interest harboring the mutations T478K, P681H, and T732A in the Spike protein, within the newly named lineage B.1.1.519, which rapidly outcompeted the preexisting variants in Mexico and has been the dominant virus in the country during the first trimester of 2021.
Databáze: OpenAIRE