Three new sesquiterpenoids from the stems of Strophanthus divaricatus

Autor:	Hao Wang, Sheng-Zhuo Huang, Rui-Jun Duan, Wen-Li Mei, Hao-Fu Dai, Hong-Ling Ran, Cui-Juan Gai, Li Yang, Ya-Li Guan, Miao Yu
Rok vydání:	2021
Předmět:	biology Chemistry Stereochemistry Plant Science biology.organism_classification Biochemistry HeLa Ic50 values Strophanthus divaricatus Cytotoxicity Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Human cancer Biotechnology
Zdroj:	Phytochemistry Letters. 46:100-104
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2021.09.010
Popis:	Three new aromadendrane-type sesquiterpenoids (1–3) and five known compounds (4–8) were isolated from the stems of Strophanthus divaricatus. Their structures were determined by spectroscopic methods including HR-ESI-MS, 1D and 2D NMR. The absolute configurations of 1–3 was determined by comparison of the experimental and computed ECD spectra. Neridienone A (6) exhibited significant cytotoxicity against human cancer cell lines BEL-7402, SGC-7901, K562, A549, and HeLa with IC50 values of 3.30 ± 0.01, 2.25 ± 0.01, 2.02 ± 0.03, 1.55 ± 0.01, 4.73 ± 0.07 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4571701d7f26c56febf082a6f6a9fb78 https://doi.org/10.1016/j.phytol.2021.09.010 Zobrazit plný text záznamu Full Text from ScienceDirect