HAb18G/CD147 is involved in TGF-β-induced epithelial-mesenchymal transition and hepatocellular carcinoma invasion
| Autor: | Jiao Wu, Huijie Bian, Zhi-Nan Chen, Ning-Yu Ru |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
biology
Slug Chemistry Vimentin Cell Biology General Medicine Transforming growth factor beta biology.organism_classification medicine.disease Metastasis Downregulation and upregulation Cell culture embryonic structures Immunology medicine biology.protein Cancer research Epithelial–mesenchymal transition Transforming growth factor |
| Zdroj: | Cell Biology International. 39:44-51 |
| ISSN: | 1065-6995 |
| DOI: | 10.1002/cbin.10341 |
| Popis: | Epithelial-mesenchymal transition (EMT) induced by the transforming growth factor beta (TGF-β) is involved in hepatocarcinogenesis and hepatocellular carcinoma (HCC) metastasis. HAb18G/CD147, a member of the immunoglobulin family, plays an important role in tumor invasion and metastasis. HAb18G/CD147 promotes EMT of hepatocytes through TGF-β signaling and is transcriptionally regulated by Slug. We investigated the role of HAb18G/CD147 in TGF-β-induced EMT in HCC invasion. Two human HCC cell lines, SMMC-7721 and HepG2, were used to determine the role of HAb18G/CD147 in EMT. Upregulation of HAb18G/CD147 induced by the high doses of TGF-β1 in SMMC-7721 (5 ng/mL) and HepG2 cells (10 ng/mL) (P |
| Databáze: | OpenAIRE |
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