Immediate and remote effects of antitumor drug on the morphology of rat liver
Autor: | V. E. Gol’dberg, T. I. Fomina, M. V. Filipova, Gol'dberg Ed, T. V. Vetoshkina, T. Yu. Dubskaya |
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Rok vydání: | 1998 |
Předmět: | |
Zdroj: | Bulletin of Experimental Biology and Medicine. 126:1140-1143 |
ISSN: | 1573-8221 0007-4888 |
Popis: | Experiments performed on rats have shown that a single intravenous injection of the antitumor preparations platidiam and pharmorubicine in the maximum tolerated dose cause morphological changes in the liver which are preserved for 3 months after platidiam and for 6 moths after pharmorubicine. Instability of reparative processes in the liver was revealed when the rats were poisoned with CCl4, 1, 3, and 6 months after administration of the cytostatics. |
Databáze: | OpenAIRE |
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