Effect of hGH on somatomedin (SM) A & B in GH deficiency

Autor:	S J Bodden, J.W. Williams, B T Rudd, S L Schwalbe, P H W Rayner
Rok vydání:	1978
Předmět:	medicine.medical_specialty Basal (phylogenetics) Endocrinology Chemistry Internal medicine Pediatrics Perinatology and Child Health medicine Bioassay SMA Linear growth Somatomedin GH Deficiency
Zdroj:	Pediatric Research. 12:163-163
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-197802000-00104
Popis:	Se SMA (bioassay) and SMB (RI assay) have been measured in children with GH deficiency following IM injection of hGH and the response correlated with subsequent linear growth. 14 patients (9M, 5F) aged 6-20 yrs were given hGH 10 mgs IM and SMA & B monitored at intervals for 48 hrs after a first and 24 hrs after a second injection. Peak SMA & B values and times were unpredictable, varying between 3 and 48 hrs. The sum of increments for SMA & B were calculated and values greater than 50% above basal were taken as significant. Eight patients showed a positive SMA response and 10 a positive SMB response after the first injection but only 4 SMA & 2 SMB responses occurred after the second. Three patients failed to show an SMB increase after either, although SMA rose. No correlation between SMA & B increments was found, and no correlation was demonstrated with linear growth response to hGH.
Databáze:	OpenAIRE
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