Autocrine action of IL-10 suppresses proinflammatory mediators and inflammation in the HSV-1-infected cornea

Autor:	Robert N. Lausch, Minsheng Zhuang, Xiao-Tian Yan, John E. Oakes
Rok vydání:	2001
Předmět:	Chemokine Corneal Diseases Immunology Inflammation Cell Biology Biology Corneal inflammation Proinflammatory cytokine Paracrine signalling medicine biology.protein Immunology and Allergy medicine.symptom Receptor Autocrine signalling
Zdroj:	Journal of Leukocyte Biology. 69:149-157
ISSN:	1938-3673 0741-5400
DOI:	10.1189/jlb.69.1.149
Popis:	We investigated whether IL-10 produced endogenously would influence the development of HSV-1-induced acute corneal disease. Murine corneal epithelial cells and fibroblasts cultured in vitro expressed IL-10 mRNA and protein constitutively and also IL-10 receptors. Inclusion of IL-10 neutralizing antibody in the culture medium significantly (p
Databáze:	OpenAIRE
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