Associations between grass pollen exposures in utero and in early life with food allergy in 12-month-old infants
| Autor: | Mimi L.K. Tang, Adrian J. Lowe, Shyamali C. Dharmage, Noor H. A. Suaini, Jennifer J. Koplin, Anne-Louise Ponsonby, Katrina J. Allen, Agus Salim, Nugroho Harry Susanto, Bircan Erbas |
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| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Population Peanut allergy Physiology 010501 environmental sciences medicine.disease_cause 01 natural sciences 03 medical and health sciences 0302 clinical medicine Food allergy Pollen otorhinolaryngologic diseases medicine 030212 general & internal medicine education 0105 earth and related environmental sciences education.field_of_study Pregnancy Public Health Environmental and Occupational Health food and beverages General Medicine Odds ratio medicine.disease Pollution In utero Cohort |
| Zdroj: | International Journal of Environmental Health Research. 32:712-722 |
| ISSN: | 1369-1619 0960-3123 |
| Popis: | Birth during pollen seasons may influence food allergy risk but no study has assessed pollen exposure. Using the HealthNuts population-based cohort of 5276 infants, we assessed grass pollen exposures, in utero and up to the first 6 months of life, on hen's egg, sesame and peanut allergy outcomes at 12 months. Cumulative pollen exposure in the first 7 days of life increased risk of peanut sensitization aMOR (adjusted multinomial odds ratio) = 1.21 (95% CI: 1.01-1.44). Exposure between first 4-6 months of life increased risk of hen's egg aMOR = 1.02 (95% CI: 1.004-1.04) and sensitization to all foods aMOR = 1.02 (95% CI: 1.003-1.04). Grass pollen exposure was associated with food challenge diagnosed food allergy, but only among infants with a maternal history of food allergy. Exposure to grass pollen in the intrauterine period and infancy may be important but more studies are needed to replicate these findings. |
| Databáze: | OpenAIRE |
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