Lupus-erythematosus-Like Eruption Induced by Trichophyton mentagrophytes Infection
| Autor: | Franck Boralevi, Christine Léauté-Labrèze, S. Roul, B. Couprie, Alain Taïeb |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Systemic disease
Systemic lupus erythematosus Lupus erythematosus macromolecular substances Dermatology Biology medicine.disease biology.organism_classification Connective tissue disease immune system diseases Immunopathology parasitic diseases Immunology medicine Trichophyton skin and connective tissue diseases Mycosis Kerion |
| Zdroj: | Dermatology. 206:303-306 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000069941 |
| Popis: | Background: Several factors are known to trigger acute manifestations of lupus erythematosus (drugs, ultraviolet radiation, bacterial or viral infections, pregnancy), but fungal infections have never been reported to induce lupus-like lesions. We describe 2 children with tinea capitis caused by Trichophyton mentagrophytes (TM), who developed transient skin and serological manifestations of systemic lupus erythematosus. Patients: Case 1, a 3-year-old girl, had a kerion due to TM transmitted by an octodon, and a facial skin eruption suggestive of systemic lupus erythematosus. Antinuclear antibodies (ANA) were positive at 1:250. After griseofulvin treatment, the lupus-like rash completely regressed, and the ANA titre decreased. Case 2, a 4-year-old girl, had occipital kerion and an annular scaly erythema on the shoulder caused by TM. She also had a non-scaly rash on the face and a recent history of photosensitivity. The ANA titre was positive at 1:8,000. Cutaneous lesions disappeared after an 8-week griseofulvin therapy, and ANA titres decreased progressively. Conclusions: ‘New pets’ are usually the vectors of TM, especially familiar rodents like the degu of Chile (also named octodon). In our 2 cases, lupus-like rashes began before the onset of griseofulvin treatment, suggesting a pathogenic role of the dermatophyte. A wide variety of lesions named ‘mycides’ was described several decades ago associated with TM infections. We hypothesize that these mycides and the TM-induced lupus-like lesions reported in our 2 cases could represent the same entity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|