Light and drug distribution with topically administered photosensitizers

Autor:	Bruce J. Tromberg, Michael W. Berns, M. T. Wyss-Desserich, Lars O. Svaasand, Pius Wyss, Yona Tadir
Rok vydání:	1996
Předmět:	medicine.medical_specialty Protoporphyrin IX medicine.medical_treatment Photodynamic therapy Dermatology medicine.disease Photobleaching Light dose chemistry.chemical_compound chemistry medicine Distribution (pharmacology) Dosimetry Surgery Basal cell carcinoma Irradiation Biomedical engineering
Zdroj:	Lasers in Medical Science. 11:261-265
ISSN:	1435-604X 0268-8921
DOI:	10.1007/bf02134917
Popis:	Photodynamic therapy (PDT) based on topical application of photosensitizers is currently in clinical use for the treatment of basal cell carcinoma of the skin, and it has been evaluated in animal models for photo-ablation of the endometrium. This paper presents a dosimetry model which indicates that a limiting factor in treating thick tumours will be the transport of the drug into the tumour rather than depletion of the optical distribution. The model predicts that an optical irradiation of 100 mW cm−2 at 635 nm for 20 min, ie well below the threshold for hyperthermic reaction, will give an adequate light dose to a depth of 3 mm. The time required for photosensitizers to diffuse to this depth is in the range of 3–15 h, dependent on the diffusion properties of the tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::454d4dda569cbd96cc72eb478ab834dc https://doi.org/10.1007/bf02134917 Zobrazit plný text záznamu Full text from SpringerLink