ChemInform Abstract: Enantioselective Synthesis of Fusarentin Methyl Ethers: Insecticidal Metabolites of Fusarium larvarum

Autor:	Thomas J. Simpson, Carole McNicholas, Nicola J. Willett
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Acylation chemistry.chemical_compound Ketone chemistry Enantioselective synthesis Ether General Medicine Medicinal chemistry Fusarium larvarum
Zdroj:	ChemInform. 28
ISSN:	0931-7597
Popis:	Fusarentin 4,5-dimethyl ether ( 1 ) and its 4-desmethoxy analogue are synthesised via acylation of the benzylic anion of N , N -dimethyl-2,3,4,-trimethoxy-6-methylbenzamide ( 9 ) and N , N -dimethyl-2,4-dimethoxy-6-methylbenzamide ( 8 ) with N -methoxy- N -methyl-( S )-3- tert -butyldimethylsilyloxyhexanamide ( 13 ): subsequent reduction of ketone ( 15 ) to the anti -1,3-diol ( 16 ) and acid catalysed cyclisation gives ( 1 ).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4548e685f711afef579b7e55ff54c621 https://doi.org/10.1002/chin.199707276 Zobrazit plný text záznamu Plný text