ChemInform Abstract: 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a New Protecting Reagent in Peptide Synthesis

Autor:	M. G. Gorbunova, Valery P. Kukhar, S. V. Galushko, Igor I. Gerus
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Stereochemistry General Medicine Amino acid chemistry.chemical_compound Hydrolysis chemistry Reagent Peptide synthesis Alkoxy group Peptide bond Organic chemistry Protecting group Racemization
Zdroj:	ChemInform. 22
ISSN:	0931-7597
DOI:	10.1002/chin.199137255
Popis:	The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.
Databáze:	OpenAIRE
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