Effects of smoking during pregnancy on retinopathy of prematurity

Autor: S. Fernandez, I. González‐Viejo, M Ara, E Prieto, M.J. Rodrigo, G De La Mata, C. Ferrer, Victoria Pueyo
Rok vydání: 2015
Předmět:
Zdroj: Acta Ophthalmologica. 93
ISSN: 1755-375X
Popis: Purpose Background: Tobacco smoking during pregnancy is the first preventable cause of adverse birth outcomes such as vascular and neurodevelopment disturbation. Aims: To asses how smoking during pregnancy would affect retinal vascularization causing retinopathy of prematurity. Design: An observational cross-sectional study. Methods Records of preterm newborns (n = 293) and tobacco expossure were reviewed. Retinopathy of prematurity (ROP) grading was evaluated in accordance with the International Classification of Retinopathy of Prematurity. Factors were evaluated using a multivariate logistic regression analysis Results Although most children did not develop ROP (74.1%), 10.9% has mild, 9.6% severe and 5.5% aggressive posterior retinopathy. Twenty percent of mothers smoked during pregnancy and 10.2% smoked ≥5 cigarettes per day. Children of smoking mothers showed higher rate of Anterior Progressive ROP (6.9%) than those who were not expossed (5.1%), and as much severe as higher number of cigarettes (10.9% vs 5.1%). However, these results were not statsically significative (p > 0.05). Conclusions A tendency to higher severity grades of ROP in connection with heavy tobacco exposure during pregnancy was observed.
Databáze: OpenAIRE