Analyzing the Effectiveness of Adipose Tissue Stem Cell and Microvesicle Therapy in Premature Skin Aging Caused by Chronic Exposure to Ultraviolet Radiation
| Autor: | Kamilla Idrisova, J. Bek, Valeriia Syromiatnikova, Ruslan Masgutov, Victoria James, Marina O. Gomzikova, D. Andreeva, Galina Masgutova, Adelya Mullakhmetova, Emmanuel Kabwe, Albert A. Rizvanov |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty integumentary system business.industry Photoaging Microvesicle Regeneration (biology) Mesenchymal stem cell Biomedical Engineering Adipose tissue Bioengineering medicine.disease Microcirculation Skin Aging 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Stem cell business |
| Zdroj: | BioNanoScience. 10:991-997 |
| ISSN: | 2191-1649 2191-1630 |
| Popis: | Adipose-derived mesenchymal stem cells (ADSCs) and microvesicles (MVs) isolated from ADSCs are promising therapeutic agents for various pathological and physiological skin conditions. Investigate the effects of ADSC and MV therapy on skin regeneration under photoaging conditions in vivo. CD-1 mice were exposed to a course of UV radiation exposure for 6 weeks. After 4 weeks, the animals were injected by multiple intradermal punctures with ADSCs, MVs, or PBS. To analyze the effectiveness of ADSCs and MVs, changes in the microcirculation within the dorsal skin of the mice was assessed using laser Doppler flowmetry. Morphometric and morphological assessment of histological changes were also performed. No differences in skin perfusion were identified at 4 weeks post-injection of ADSCs and MVs. However, histological analysis showed treatment with ADSCs and MVs both led to a decrease in UV-mediated epidermal thickening and improved organization of the dermal layer. ADSC- and ADSC-MV-based therapy acts to prevent skin damage caused by UV photoaging. |
| Databáze: | OpenAIRE |
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