Selective Effects of Dehydroepiandrosterone Sulfate on Corticoliberin-Induced Anxiety
| Autor: | O. G. Semenova, Elena A. Vershinina, V. V. Rakitskaya, V. G. Shalyapina, Natalia Ordyan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Elevated plus maze medicine.drug_class business.industry General Neuroscience T-maze Anxiolytic chemistry.chemical_compound Dehydroepiandrosterone sulfate Endocrinology chemistry Internal medicine medicine Anxiety Nasal administration medicine.symptom business Active group |
| Zdroj: | Neuroscience and Behavioral Physiology. 42:257-263 |
| ISSN: | 1573-899X 0097-0549 |
| Popis: | The effects of dehydroepiandrosterone sulfate (DHEA-S) on changes in the levels of anxiety induced by administration of the stress neurohormone corticoliberin were studied. A T maze was used to select Wistar rats with active and passive strategies of adaptive behavior. Testing of the active group in an elevated plus maze was used to select low- and high-anxiety individuals. Intranasal administration of corticoliberin to low-anxiety active rats resulted in decreases in total activity and increases in the level of anxiety, while high-anxiety animals had low sensitivity to this neurohormone. Prior administration of DHEA-S at a dose of 3 mg/100 g had antistress effects in low-anxiety rats and anxiolytic effects in high-anxiety rats. In passive animals, which were characterized by initially high levels of anxiety and were resistant to corticoliberin, administration of DHEA-S also had antistress actions. These results led to the conclusion that the effects of DHEA-S depended on the initial psychoemotional state and behavioral sensitivity to corticoliberin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink