Increased corneal sub-basal nerve density in patients with Sjögren syndrome treated with topical cyclosporine A

Autor:	Christophe Baudouin, Vincent Borderie, B. Dupas, Laurent Laroche, Ora Levy, Nacim Bouheraoua, Taous Hamiche, Antoine Labbé
Rok vydání:	2017
Předmět:	0301 basic medicine medicine.medical_specialty business.industry Sjögren syndrome medicine.disease Ophthalmic nerve Surgery 03 medical and health sciences Ophthalmology Basal (phylogenetics) 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Refractory Cornea 030221 ophthalmology & optometry medicine Ocular Surface Disease Index In patient business Prospective cohort study
Zdroj:	Clinical & Experimental Ophthalmology. 45:455-463
ISSN:	1442-6404
DOI:	10.1111/ceo.12898
Popis:	Background To evaluate quantitative and qualitative changes in subbasal corneal nerves (SBN) via in vivo confocal microscopy (IVCM) in patients with Sjogren syndrome dry eye (SSDE) treated with topical cyclosporine A (CsA). Design Prospective, observational, non-randomized study. Participants Thirty eyes of 30 patients with SSDE refractory to conventional treatment treated with CsA 0.05% twice daily for six months. Fifteen eyes of 15 healthy, age and gender matched, volunteers constituted the control group at baseline. Methods A clinical evaluation of dry eye (DE), corneal sensation using Cochet-Bonnet esthesiometry and IVCM analysis of the central cornea were performed prospectively at baseline for all patients, and after six months of treatment with CsA. Main outcome measures Density, number, reflectivity and tortuosity of SBN, dendritic cell (DC) density, esthesiometry, and DE signs and symptoms. Results Topical CsA 0.05% improved clinical signs and symptoms, and increased corneal sensitivity. Following treatment, SBN density was significantly increased (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4540490e73c5dfd6973f7bd2b56a9e95 https://doi.org/10.1111/ceo.12898 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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