Invasive Candida Infections in a Pediatric Intensive Care Unit in Turkey: Evaluation of an 11-Year Period
| Autor: | Özden Özgür Horoz, Dincer Yildizdas, Ahmet Yontem, Emine Kocabaş, Nagehan Aslan, Derya Alabaz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pediatric intensive care unit
medicine.medical_specialty biology business.industry Mortality rate Micafungin 030208 emergency & critical care medicine Retrospective cohort study Critical Care and Intensive Care Medicine biology.organism_classification Corpus albicans 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health medicine Candida albicans business Prospective cohort study Fluconazole medicine.drug |
| Zdroj: | Journal of Pediatric Intensive Care. :021-026 |
| ISSN: | 2146-4626 2146-4618 |
| Popis: | The aim of this study was to evaluate the Candida species, predisposing factors, antifungal treatment approaches, and clinical outcomes of invasive Candida infections (ICIs) in a tertiary pediatric intensive care unit (PICU). A retrospective study was performed from January 2008 to January 2019 including 102 children with ICIs who were admitted to a university hospital in southeastern Turkey. Positive blood cultures were detected in 43 (42.1%) patients, and positive urine cultures were detected in 59 (57.8%). According to our results, Candida albicans (42.2%) was the most common species for all isolates followed by C. parapsilosis (17.6%). In our patient population, non-albicans Candida species were dominant (57.8%) in all isolates. The most common facilitating factor in our study was the use of mechanical ventilator support (87.3%). The mortality rate of our patients with ICIs was 13.7%. Candida albicans was found to have the highest mortality rate among all Candida species (30.7%). When we compared patients with C. albicans and those with non-albicans Candida species in terms of risk factors, we detected a significant difference between the two groups for total parenteral nutrition use (p = 0.027). Fluconazole was the most preferred (58.8%) treatment option in our PICU for ICIs. Our results showed an increased trend in micafungin use in recent years. ICIs are a significant problem due to the high mortality and morbidity rates in critically ill pediatric patients in PICUs. In recent years, an increase in Candida infections caused by non-albicans Candida species has been reported. Multicenter prospective studies are needed to determine the risk factors for ICIs. |
| Databáze: | OpenAIRE |
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