Synthesis and Cytotoxicity Studies of Silyl-Substituted Titanocene Dichloride Derivatives
| Autor: | Matthias Tacke, Helge Müller-Bunz, Anthony Deally, Frauke Hackenberg, Grainne Lally |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cyclopentadiene
Dimethylsilane Organic Chemistry Titanocene dichloride chemistry.chemical_element Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound Transmetalation Cyclopentadienyl complex chemistry Titanium tetrachloride Organic chemistry Physical and Theoretical Chemistry Fulvene Titanium |
| Zdroj: | Organometallics. 31:5782-5790 |
| ISSN: | 1520-6041 0276-7333 |
| DOI: | 10.1021/om300227h |
| Popis: | Six new titanocene compounds have been isolated and characterized. These compounds were synthesized from their silyl-substituted fulvene or cyclopentadiene precursors using Super Hydride (LiBEt3H) or n-BuLi, followed by transmetalation with titanium tetrachloride, to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((phenyl)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3a), bis-[((4-methoxyphenyl)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3b), bis-[((4-N,N-dimethylmethanamine)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3c), bis-[((4-N,N-diethylmethanamine)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3d), bis-[((1-methyl-5-trimethylsilyl)indol-3-yl)methylcyclopentadienyl] titanium(IV) dichloride (4e), and bis-[((1-methyl-3-diethylaminomethyl-5-trimethylsilyl)indol-2-yl)methylcyclopentadienyl] titanium(IV) dichloride (4f). The two titanocenes 3a and 3b were crystallized and characterized by X-ray crystallography, while ... |
| Databáze: | OpenAIRE |
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