Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities

Autor:	Wei-Hai Liu, Yu-Yang Yi, Zhi-Xiu Lin, Zhen Qin, Zi-Ren Su, Xiao-Ping Lai, Hui-Jun Liao, Zheng-Quan Lai, Siu-Po Ip
Rok vydání:	2014
Předmět:	Hep G2 Picrasma quassioides biology Traditional medicine Chemistry Cell culture Alkaloid Cytotoxic T cell Plant Science General Chemistry Cancer cell lines biology.organism_classification General Biochemistry Genetics and Molecular Biology
Zdroj:	Chemistry of Natural Compounds. 50:884-888
ISSN:	1573-8388 0009-3130
Popis:	A new alkaloid, 6-hydroxy-β-carboline-1-carboxylic acid (1), together with six known alkaloids, including β-carboline-1-carboxylic acid (2), β-carboline-1-propanoic acid (3), 1-methoxycarbonyl-β-carboline (4), 3-methylcanthin-5,6-dione (5), 5-hydroxy-4-methoxycanthin-6-one (6), and 4,5-dimethoxycanthin-6-one (7), were isolated from the stem of Picrasma quassioides. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–7 were screened for their cytotoxic activities against five cancer cell lines such as CT26.WT, K-562, SGC-7901, Hep G2, and A-549. Among the seven alkaloids tested, only compound 2 exhibited moderate inhibitory activities against K-562 and SGC-7901 cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::453dcb2db3e39d9fa4cd4182fed7bef2 https://doi.org/10.1007/s10600-014-1106-6 Zobrazit plný text záznamu Plný text ve formátu PDF