Incidence and survival for childhood central nervous system tumours in Australia, 1983–2016
| Autor: | Danny R. Youlden, Tim Hassall, Joanne F. Aitken, Nicholas G. Gottardo, Chloe Henshaw |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty education.field_of_study Childhood Cancer Registry Neurology Relative survival business.industry Incidence (epidemiology) Central nervous system Population Astrocytoma medicine.disease Gastroenterology medicine.anatomical_structure Oncology Internal medicine Cohort medicine Neurology (clinical) business education |
| Zdroj: | Journal of Neuro-Oncology. 155:203-213 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-021-03869-6 |
| Popis: | To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. Relative survival was calculated using the cohort method, with changes in survival over time by cancer type and tumour grade assessed by multivariable flexible parametric survival modelling. The study cohort included 4914 patients, with astrocytoma (n = 2181, 44%) and embryonal tumours (n = 931, 19%) the most common diagnostic subgroups. Almost half (n = 2181, 44%) of all tumours were classified as high grade (III or IV). Incidence rates increased by 29% between 1983 and 2016, with high grade tumours rising by an annual average of + 1.1% (95% CI = + 0.7%, + 1.5%, p |
| Databáze: | OpenAIRE |
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