[11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET-ligand development

Autor:	Oleksiy Itsenko, Bengt Langstrom, Obaidur Rahman
Rok vydání:	2007
Předmět:	Microdosing Organic Chemistry Nanotechnology Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry Labelling Drug Discovery Pet ligand Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy Carbon monoxide
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 50:794-810
ISSN:	1099-1344 0362-4803
DOI:	10.1002/jlcr.1446
Popis:	In this review the recent progress in the development of suitable precursors for 11 C-labelling is discussed. Especially the last few years' advancement of the use of ( 11 C) carbon monoxide as a versatile and useful precursor in labelling chemistry is presented. The development is set in perspective of its potential in applying molecular imaging tools in drug and tracer development.The possibility of exploring small tracer libraries utilizing the microdosing concept is explored. Copyright # 2007 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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