Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
| Autor: | Aleksandra Aracki-Trenkic, Slobodan Vojinovic, Dragan Stojanov, Daniela Benedeto-Stojanov, Srdjan Ljubisavljevic |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Gadolinium chemistry.chemical_element 030218 nuclear medicine & medical imaging Gadobutrol 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging In patient medicine.diagnostic_test Cumulative dose business.industry Multiple sclerosis Magnetic resonance imaging General Medicine medicine.disease Globus pallidus Dentate nucleus nervous system chemistry Radiology business Nuclear medicine 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Radiology. 26:807-815 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-015-3879-9 |
| Popis: | To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS). Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96–98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections. Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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