Facile multi-component one-pot synthesis of 4-amidoaralkyl-3-hydroxyquinolines using ZnO NPs: Evaluation of anti-bacterial and anti-diabetic activity

Autor:	K.T.V. Rao, Hima G. Bindu, Paul S. Douglas
Rok vydání:	2022
Předmět:	Renewable Energy Sustainability and the Environment General Chemical Engineering General Earth and Planetary Sciences General Chemistry General Agricultural and Biological Sciences Biochemistry General Environmental Science
Zdroj:	Research Journal of Chemistry and Environment. 26:85-93
ISSN:	2278-4527 0972-0626
DOI:	10.25303/2603rjce8593
Popis:	A three-component one-pot synthesis was performed to obtain 4-amidoaralkyl-3-hydroxyquinolines (4a-j), belonging to heterocyclic class of compounds. These derivatives were obtained by the fusion of 3- hydroxyquinoline (1), aromatic aldehydes (2a-j) and amides (3a-j) in the presence of ZnO nanoparticles under solvent free conditions at 40oC temperature. Using 1HNMR, 13CNMR, FTIR spectral techniques and LC-MS analytical technique, the structural and elemental aspects of the derivatives have been confirmed. Higher yields and less reaction time (1.5 h) were the major outcomes of the protocol and further, greater recoverability of ZnO NPs was observed. The anti-bacterial activity of the quinoline derivatives (1st cycle) has been evaluated against Staphylococcus aureus and Escherichia coli organisms. Anti-diabetic activity was also tested against insulin as the standard. It was found that the majority of the derivatives (4a-j) possessed greater biological activities in both the performed investigations.
Databáze:	OpenAIRE
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