The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review
| Autor: | Zeng-Rui Zhang, Xing-Ru Zhang, Cheng-Long Xie, Jincai He, Ke Wu, Huijun Chen, Zhi-Yu Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology Levodopa medicine.medical_specialty Parkinson's disease business.industry Incidence (epidemiology) Pharmaceutical Science medicine.disease Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Dyskinesia Oral administration 030220 oncology & carcinogenesis Internal medicine Drug Discovery medicine Levodopa carbidopa medicine.symptom Adverse effect business medicine.drug |
| Zdroj: | Drug Design, Development and Therapy. 14:845-854 |
| ISSN: | 1177-8881 |
| Popis: | Background Levodopa-carbidopa intestinal gel (LCIG) is a new type of administration that results in steadier levodopa plasma concentrations in advanced Parkinson's disease (PD) patients and effectively reduces poor mobility and dyskinesia. Methods Electronic databases were searched up to January 1, 2018. The inclusion criteria for this review were as follows: LCIG vs oral medication in advanced PD patients. Results Five trials, with a total of 198 patients, met all the inclusion criteria. The quality score of these studies ranged from 3 to 5. Two clinical trials showed that compared with oral medication, LCIG had a better treatment effect on on-time with troublesome dyskinesia (TSD) (p = 0.02) and on-time without TSD (p < 0.00001) in advanced PD patients. In addition, four of the 5 studies showed that the LCIG may have better efficacy than oral medication for improving the scores of the UPDRS, and two studies found that LCIG demonstrated better efficacy for improving the PDQ-39 scores. The video recording results indicated a potential decline in both dyskinesia and the "off" state in LCIG-treated patients. The incidence of adverse events was not significantly different between the LCIG and oral medication groups. Conclusion Compared with oral treatment, LCIG exerts its effectiveness, mostly by reducing the time of on-time with TSD, increasing the time of on-time without TSD and scores of UPDRS and PDQ-39. It is suggesting that LCIG was likely to be a new type of administration used in clinical applications. However, due to methodological flaws, these findings should be viewed with caution, and more RCTs are needed in the field to complement our findings. |
| Databáze: | OpenAIRE |
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