Application of Liquid- and Supercritical Fluid Chromatography Coupled with High-Resolution Mass Spectrometry for the Analysis of Short-, Medium-, and Long-Chain Chlorinated Paraffins in Dietary Supplements

Autor:	Jakub Tomasko, David Maxa, Klara Navratilova, Tomas Kourimsky, Vojtech Hrbek, Jana Hajšlova, Jana Pulkrabova
Rok vydání:	2022
Předmět:	Analytical Chemistry
Zdroj:	LCGC Europe. :7-11
ISSN:	2767-7095 1471-6577
DOI:	10.56530/lcgc.eu.qd8477p7
Popis:	Chlorinated paraffins (CPs) are an emerging and ubiquitous group of environmental pollutants associated with adverse effects on human health, including endocrine disruption and possible carcinogenicity. In this study, supercritical fluid chromatography (SFC) and ultrahigh-performance liquid chromatography (UHPLC) — both coupled with high-resolution mass spectrometry (HRMS) — methods for the analysis of short-, medium-, and long-chain CPs in fish oil-based dietary supplements were developed and validated at concentration levels of 0.6 and 3.0 µg/g lipid weight (lw). The recoveries were in the range of 80–96% and repeatabilities, expressed as relative standard deviations, were
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4501a17fc5cecdd7cf224c8b11acdcc8 https://doi.org/10.56530/lcgc.eu.qd8477p7 Zobrazit plný text záznamu