NMR interaction studies of aromatic guanyl hydrazones with micelles: Model for mechanism of action of cationic antibiotics
| Autor: | José Daniel Figueroa-Villar, Márcia Narcizo Borges |
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| Rok vydání: | 2000 |
| Předmět: |
Stereochemistry
Antiparasitic medicine.drug_class Organic Chemistry Relaxation (NMR) Biophysics Cationic polymerization General Medicine Biochemistry Micelle Biomaterials Cell membrane chemistry.chemical_compound medicine.anatomical_structure Membrane chemistry Mechanism of action Bromide medicine medicine.symptom |
| Zdroj: | Biopolymers. 62:9-14 |
| ISSN: | 1097-0282 0006-3525 |
| Popis: | Interaction studies using hydrogen NMR spin-lattice relaxation time measurements of a series of five antiparasitic guanyl hydrazones with SDS and cetyl trimethylammonium bromide micelles are used as a simple model for the interaction of these compounds with the cell membrane of Trypanosoma cruzi. The results show that the activity of the compounds is related to their capacity to selectively interact with anionic micelles, which reinforces the hypothesis that the mechanism of action of these compounds is related to their selective interaction with the negatively charged parasite membrane. |
| Databáze: | OpenAIRE |
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