A general approach toward the design of mechanism-based inactivators of serine proteinases: inactivation of human leukocyte elastase by a phthalimide derivative
| Autor: | Lee S. Chong, Radhika Venkataraman, Jeffrey B. Epp, He Huang, Rongze Kuang, William C. Groutas |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Leukocyte elastase Mechanism based Biochemistry Human Leukocyte Elastase Phthalimide Serine proteinases chemistry.chemical_compound Enzyme Enzyme inhibitor Drug Discovery biology.protein Molecular Medicine Molecular Biology Derivative (chemistry) |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2745-2750 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80756-3 |
| Popis: | A general approach toward the design of mechanism-based inhibitors of serine proteinases involving the linking of fragment -CHX-COOR to an appropriate recognition element is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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