Effects of ethynodiol diacetate and mestranol in rats and rabbits, on conception, on the outcome of pregnancy and on the offspring

Autor:	Francis J. Saunders, Richard L. Elton
Rok vydání:	1967
Předmět:	Pharmacology medicine.medical_specialty Pregnancy Offspring Anogenital distance Biology Toxicology medicine.disease Mestranol Endocrinology Internal medicine medicine Ethynodiol Diacetate medicine.drug
Zdroj:	Toxicology and Applied Pharmacology. 11:229-244
ISSN:	0041-008X
DOI:	10.1016/0041-008x(67)90066-x
Popis:	Ethynodiol diacetate and mestranol, separately or in combination, prevent establishment of pregnancy in rats and rabbits when administered in sufficient dosage. This property is common to estrogens in these species. Treatment of pregnant rats with ethynodiol diacetate and mestranol did not produce birth defects. Measurement of the anogenital distance did not disclose any masculinizing effect on the female young nor any feminizing effect on the male offspring. Furthermore, at maturity these young were shown to be fertile. The incidence of birth defects in rabbits was not increased by treatment with ethynodiol diacetate throughout pregnancy. The offspring were fertile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::44e57175ec896d6133227468554f8c4e https://doi.org/10.1016/0041-008x(67)90066-x Zobrazit plný text záznamu