Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?

Autor:	Carolina Di Somma, Elisabetta Scarano, Rossana Arianna, Fiammetta Romano, Mariarosaria Lavorgna, Domenico Serpico, Annamaria Colao
Rok vydání:	2023
Předmět:	General Medicine
Zdroj:	Journal of Clinical Medicine. 12:662
ISSN:	2077-0383
DOI:	10.3390/jcm12020662
Popis:	Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::44ddf02c1c4848cbd6ae589f89b23c03 https://doi.org/10.3390/jcm12020662 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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