| Autor: |
Jens Roar Bjerke, Roald Matre, Gunnar Haukenes, J. K. Livden |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Archives of Dermatology. 119:955 |
| ISSN: |
0003-987X |
| DOI: |
10.1001/archderm.1983.01650360001001 |
| Popis: |
To the Editor.— Increasing evidence points to the importance of immune mechanisms in the pathogenesis of psoriasis. The role of humoralvcellular immune reactions in the development of psoriatic skin lesions seems still to be open for discussion. In the SeptemberArchives(1982;118:652-657), Jablonska et al claimed that the polymorphonuclear leukocytes play an important role in the earliest stages of development of psoriatic lesions. Recently, we have obtained data indicating that lymphocytes and macrophages are involved in the pathogenesis of psoriasis. Macrophages and T cells are regularly found in early psoriatic lesions. There is great variation in the relative proportions of these cells, depending on the clinical activity of the disease.1When monoclonal antibodies against T-cell surface antigens are used, both helper-inducer and suppressor-cytotoxic T cells can be demonstrated.2To determine the functional state of T cells in the psoriatic plaque, we have studied the presence of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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