Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents
| Autor: | Oleg A. Rakitin, Yu. E. Sabutskii, Vladimir A. Ogurtsov, Sergey G. Polonik, Roman S. Popov, Sergey N. Fedorov, Alexandra S. Kuzmich, Alla G. Guzii |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Human leukemia
Transcriptional activity integumentary system 010405 organic chemistry Chemistry Chlorine atom Cancer General Chemistry 010402 general chemistry medicine.disease 01 natural sciences Combinatorial chemistry 0104 chemical sciences Soft agar 3h 1 2 dithiole 3 thione medicine Nucleophilic substitution Conjugate |
| Zdroj: | Russian Chemical Bulletin. 70:573-579 |
| ISSN: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-021-3127-1 |
| Popis: | Nucleophilic substitution of a chlorine atom in 4,5 dichloro-1,2-dithiole-3-thione with per-O-acetyl-1-mercaptho derivatives of d-glucose, d-galactose, d-mannose, d-xylose, l-arabinose, and d-maltose gave six new acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione. These thioglycosides were shown to possess cancer preventive activity on the models of JB6 Cl41 P+ mouse epidermal cells and THP-1 human leukemia cells in soft agar, as well as to inhibit the AP-1-dependent transcriptional activity in JB6 Cl41 luc-AP-1 cells, which suggests the possibility of using the new compounds as potential cancer preventive drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink