Discoidin Domain Receptors in Cardiac Development
| Autor: | Ekaterina Mironova, Jack G. Goldsmith, Alexander J. Hartman, David E. Justus, Edie C. Goldsmith, Jay D. Potts, Adam Hoffman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
DDR1 biology Heart development Mesenchymal stem cell 02 engineering and technology 021001 nanoscience & nanotechnology Receptor tyrosine kinase Cell biology 03 medical and health sciences 030104 developmental biology biology.protein Myocyte Discoidin domain-containing receptor 2 0210 nano-technology Receptor Discoidin domain |
| Zdroj: | Discoidin Domain Receptors in Health and Disease ISBN: 9781493963812 |
| Popis: | Heart development is a complex process, involving temporally and spatially restricted morphogenic events that ultimately give rise to a multichambered heart. Discoidin domain receptors (DDRs) 1 and 2 are receptor tyrosine kinases which bind and are activated by multiple types of collagen, a structural protein found within the myocardium and valves of the heart. Both DDR1 and DDR2 are expressed in the developing heart, with DDR1 expression detected on both cardiac myocytes and fibroblasts, whereas DDR2 was only detected on fibroblasts. To date most studies examining DDRs during heart development have focused on the role of DDR2 in this process. DDR2 is upregulated on activated endothelial cells of cardiac cushions during epithelial-mesenchymal transformation associated with valve development. Inhibition of DDR2 results in incomplete transformation and a lack of mesenchymal cell formation in vitro; however, in vivo there appears to be a compensatory mechanism which allows for mesenchymal cell formation. DDR1 and DDR2 have both been implicated in fibroblast-mediated collagen remodeling. Additional studies are necessary to characterize the consequences of DDR1 or DDR2 deletion on cardiac function and to examine how these receptors may participate in matrix remodeling in cardiovascular disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|