Tabernaesines A–I, Cytotoxic Aspidosperma–Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon
| Autor: | Wen-Fang Yi, Xiao-Jiang Hao, Yuan-Zhi Chen, Tiwalade A. Adelakun, Xiao Ding, Yu Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Indole test biology Stereochemistry Organic Chemistry Pharmaceutical Science biology.organism_classification Ring (chemistry) Analytical Chemistry chemistry.chemical_compound Monomer Complementary and alternative medicine chemistry Drug Discovery Aspidosperma Molecular Medicine Cytotoxic T cell Moiety Tabernaemontana pachysiphon IC50 |
| Zdroj: | Journal of Natural Products. 83:3215-3222 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00768 |
| Popis: | Twenty-one aspidosperma-aspidosperma alkaloids, including the new tabernaesines A-J (1-9), were obtained from Tabernaemontana pachysiphon. The structures and absolute configurations were elucidated using HRMS and NMR experiments. Compounds 1-9 possessed a rare spiro heterocycle moiety between the monomeric units, while compounds 4 and 5 were characterized by an indole ring fused with an (N,N-diethyl)methyl amino group. Compounds 1, 5-7, 15, and 16 exhibited moderate cytotoxic potency against various human cancer cell lines at IC50 2.5-9.8 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|